HFIR/SNS Advanced Neutron Diffraction and Scattering workshop (HANDS 2019) | Shull Wollan Center
Oak Ridge National Laboratory, in conjunction with North Carolina State University, and support from the National Science Foundation (Award #1915748) and the Shull Wollan Center—a Joint Institute for Neutron Scattering, celebrates a decade of neutron scattering education in structural biology at ORNL with the HFIR/SNS Advanced Neutron Diffraction and Scattering workshop (HANDS 2019).
The unique potential of neutron scattering in structural biology arises from the strong interaction of neutrons with hydrogen (H) and its deuterium (D) isotope. This property makes the information available from neutron scattering unique and a valuable complement to data obtained from other structural techniques. Individual hydrogen/deuterium atoms are visualized in neutron density maps from crystallographic data at the resolution typical of most protein structures (2.0 -2.5 Å). Using H/D exchange and contrast variation, proteins and nucleic acids are sequentially modeled and mapped in large biological complexes using small angle neutron scattering. Protein-membrane interactions are revealed using reflectometry and protein and water dynamics measured using spectroscopy.
The workshop includes a symposium, lectures, and hands-on experiments at the High Flux Isotope Reactor (IMAGINE, BIO-SANS) and the Spallation Neutron Source (EQ-SANS, MaNDi, Neutron Spin Echo Spectrometer).
The workshop is designed for graduate students, post-doctoral researchers and faculty with knowledge of protein function and structure but with limited to no experience with neutron sciences.
For More Information Visit the HANDS 2019 Website